Type 2 Diabetes

Type 2 Diabetes: A Natural, Science-Based Approach to Better Blood Sugar Control

Introduction

Type 2 diabetes is one of the most common chronic health conditions worldwide, affecting millions of people across all age groups. While it is often associated with high blood sugar, the condition is much more complex than simply “eating too much sugar.” Type 2 diabetes is a metabolic disorder closely linked to insulin resistance, inflammation, excess body weight, sedentary lifestyle, poor sleep, chronic stress, and genetic predisposition.

The encouraging news is that type 2 diabetes can often be significantly improved through targeted lifestyle changes. Nutrition, physical activity, weight management, sleep quality, stress reduction, and appropriate supplementation can all play an important role in supporting healthier blood glucose levels.

A natural approach does not mean ignoring medical care. On the contrary, the most effective strategy combines evidence-based lifestyle habits with professional medical monitoring. With the right plan, many people are able to improve their blood sugar control, increase energy, support weight loss, reduce metabolic risk factors, and in some cases, even achieve remission under medical supervision.

What Is Type 2 Diabetes?

Type 2 diabetes occurs when the body becomes less responsive to insulin, the hormone responsible for helping glucose move from the bloodstream into the cells. Glucose is the body’s main source of energy, but it needs insulin to enter cells efficiently.

When cells become resistant to insulin, the pancreas tries to compensate by producing more insulin. Over time, this increased demand can place stress on the pancreas. Eventually, insulin production may decline, and blood sugar levels begin to rise consistently.

This process often develops gradually. Many people live with insulin resistance or prediabetes for years before receiving a diagnosis. That is why routine blood tests, including fasting glucose and HbA1c, are so important, especially for individuals with risk factors such as abdominal weight gain, family history of diabetes, high blood pressure, fatty liver, or a sedentary lifestyle.

Common Risk Factors

Several factors can increase the risk of developing type 2 diabetes. Some are genetic, but many are related to daily habits and metabolic health.

The most common risk factors include excess body weight, especially around the waist, lack of physical activity, a diet high in refined carbohydrates and added sugars, family history of diabetes, high blood pressure, abnormal cholesterol or triglyceride levels, fatty liver disease, poor sleep, sleep apnea, chronic stress, and aging.

Abdominal fat is especially important because it is metabolically active. It can promote inflammation and worsen insulin resistance, making it harder for the body to regulate blood sugar effectively.

Symptoms of Type 2 Diabetes

Type 2 diabetes can be silent for a long time. Some people experience no obvious symptoms, while others may notice warning signs.

Common symptoms may include increased thirst, frequent urination, fatigue, increased hunger, blurred vision, slow wound healing, recurring infections, numbness or tingling in the feet, and unexplained weight changes.

Because symptoms may be mild or absent, regular screening is essential. Blood sugar can be elevated for years before symptoms become noticeable, and during that time, damage to blood vessels, nerves, eyes, kidneys, and the heart may already be developing.

A Natural Strategy for Managing Type 2 Diabetes

A natural approach to type 2 diabetes focuses on improving insulin sensitivity, reducing blood sugar spikes, lowering inflammation, supporting healthy body weight, and strengthening overall metabolic function.

This approach is not based on quick fixes. It is based on consistent, realistic habits that can be sustained over time.

The main pillars include smart nutrition, regular movement, strength training, weight management, better sleep, stress control, hydration, medical monitoring, and carefully selected supplements when appropriate.

Nutrition for Better Blood Sugar Control

Nutrition is one of the most powerful tools for managing type 2 diabetes naturally. The goal is not necessarily to eliminate all carbohydrates, but to choose better carbohydrates, control portions, and combine them with protein, healthy fats, and fiber.

A balanced meal can help slow glucose absorption, improve satiety, and reduce sharp blood sugar spikes after eating.

Recommended foods include non-starchy vegetables, lean and high-quality proteins, healthy fats, legumes, whole grains in controlled portions, nuts, seeds, and low-glycemic fruits.

Examples of beneficial foods include leafy greens, broccoli, cauliflower, zucchini, cucumber, peppers, tomatoes, eggs, fish, poultry, tofu, plain Greek yogurt, lentils, chickpeas, beans, quinoa, buckwheat, oats, olive oil, avocado, tahini, almonds, walnuts, chia seeds, and berries.

Foods that should be limited include sugary drinks, fruit juices, sweets, cakes, cookies, white bread, white rice, regular pasta, sweetened breakfast cereals, ultra-processed snacks, and refined flour products.

The Balanced Plate Method

One of the simplest ways to build a blood-sugar-friendly meal is to use the balanced plate method.

Half of the plate should contain non-starchy vegetables. One quarter should contain a protein source.

The remaining quarter can include a controlled portion of a quality carbohydrate. A small amount of healthy fat can be added to support fullness and improve nutrient absorption.

This method is practical because it does not require complicated calorie counting.

It helps create meals that are satisfying, nutrient-dense, and easier on blood sugar.

Managing Carbohydrates Wisely

Carbohydrates have the most direct effect on blood glucose levels. However, not all carbohydrates act the same way in the body.

Refined carbohydrates are absorbed quickly and can cause sharp increases in blood sugar. Whole-food carbohydrates that contain fiber are usually absorbed more slowly and may lead to a more gradual glucose response.

Helpful strategies include eating vegetables and protein before carbohydrates, choosing whole grains instead of refined grains, avoiding sugary beverages, walking after meals, and monitoring blood sugar responses to different foods.

Personal response matters. One person may tolerate oats well, while another may experience a significant glucose spike from the same meal. This is why blood sugar monitoring can be so valuable. It allows people to personalize their nutrition instead of relying only on general rules.

Physical Activity: A Natural Tool for Insulin Sensitivity

Exercise is one of the most effective natural ways to improve insulin sensitivity. During physical activity, muscles use glucose for energy. This helps reduce blood sugar levels and improves the body’s ability to handle glucose over time.

Walking is one of the easiest and most accessible forms of exercise. Even a 10- to 15-minute walk after meals can help reduce post-meal blood sugar spikes.

Strength training is equally important. Muscle tissue plays a major role in glucose storage and metabolism. The more active muscle mass a person has, the better the body can manage blood sugar.

Effective strength exercises may include squats, wall push-ups, resistance bands, light weights, step-ups, and bodyweight movements. The goal is not perfection. The goal is consistency.

A practical weekly target is at least 150 minutes of moderate aerobic activity, combined with two to three strength-training sessions per week. People with medical conditions, heart disease, neuropathy, severe obesity, or long periods of inactivity should begin gradually and seek professional guidance.

Weight Management and Insulin Resistance

Weight loss can significantly improve blood sugar control, especially when excess weight is concentrated around the abdomen.

Even a 5% to 10% reduction in body weight may improve glucose levels, blood pressure, triglycerides, fatty liver, and insulin sensitivity.

For example, a person weighing 90 kilograms may experience meaningful metabolic benefits from losing 4.5 to 9 kilograms. This makes the goal more realistic and medically meaningful.

The most sustainable approach is not an extreme diet. It is a lifestyle built around whole foods, adequate protein, vegetables, fiber, controlled carbohydrates, healthy fats, regular movement, and better sleep.

Sleep and Blood Sugar Balance

Sleep is often overlooked, but it plays a major role in metabolic health. Poor sleep can increase insulin resistance, disrupt hunger hormones, increase cravings for high-carbohydrate foods, and raise stress hormones.

Improving sleep can support better blood sugar control and make healthy choices easier throughout the day.

Helpful sleep habits include maintaining a consistent sleep schedule, reducing screen exposure before bed, avoiding caffeine late in the day, keeping the bedroom dark and cool, avoiding heavy meals close to bedtime, and creating a calming evening routine.

People who snore heavily, wake up tired, or experience daytime sleepiness should consider being evaluated for sleep apnea. Sleep apnea is common among people with type 2 diabetes and can worsen insulin resistance if untreated.

Stress, Cortisol, and Glucose Levels

Chronic stress can raise blood sugar levels through hormones such as cortisol and adrenaline. When the body senses stress, it releases glucose into the bloodstream to prepare for action. This response can be helpful in short-term emergencies, but harmful when stress becomes constant.

Stress management is therefore a key part of natural diabetes care.

Effective tools include deep breathing, walking outdoors, meditation, mindfulness, journaling, prayer, therapy, social support, and taking short breaks throughout the day.

Even a few minutes of intentional breathing or a short walk can help calm the nervous system and support better metabolic balance.

Hydration and Alcohol

What a person drinks can have a major effect on blood sugar.

Sugary drinks are among the fastest ways to raise glucose levels. This includes soda, sweetened iced tea, energy drinks, sweetened coffee drinks, and fruit juice, even when the juice is labeled as natural.

The best choice is water. Unsweetened tea, black coffee, sparkling water, and herbal infusions can also be good options.

Alcohol should be consumed with caution. It can affect blood sugar, liver function, appetite, sleep quality, and medication safety. People taking diabetes medications should be especially careful, as alcohol may increase the risk of hypoglycemia in certain situations.

Supplements and Herbal Support

Several supplements and herbal compounds have been studied for their potential role in supporting blood sugar control. These include cinnamon, magnesium, vitamin D, alpha-lipoic acid, berberine, and astaxanthin.

Some may offer modest benefits in certain individuals, especially when there is a deficiency, increased oxidative stress, chronic inflammation, or a specific metabolic need.

However, supplements should never replace nutrition, physical activity, weight management, prescribed medication, or medical monitoring. They should be used thoughtfully and professionally, especially by people taking diabetes medications.

Astaxanthin and Blood Sugar Regulation

Astaxanthin is a naturally occurring antioxidant from the carotenoid family. It is found mainly in microalgae and in marine organisms that consume these algae, such as salmon, shrimp, and krill.

It is best known for its antioxidant and anti-inflammatory effects, but it has also attracted scientific interest for its potential role in metabolic health, insulin resistance, and blood glucose regulation.

The possible mechanism of astaxanthin in blood sugar balance is related to several complementary actions.

First, astaxanthin may help reduce oxidative stress. Oxidative stress occurs when there is an imbalance between free radicals and the body’s antioxidant defenses. In type 2 diabetes, oxidative stress is often elevated and may contribute to damage in pancreatic beta cells, which are responsible for producing insulin.

Second, astaxanthin may help reduce low-grade chronic inflammation. Chronic inflammation is strongly associated with insulin resistance. By supporting a healthier inflammatory response, astaxanthin may help improve how cells respond to insulin.

Third, astaxanthin may support mitochondrial function. Mitochondria are the energy-producing structures inside cells. Healthy mitochondrial function is important in tissues such as muscle and liver, both of which play central roles in glucose regulation.

Additionally, early research suggests that astaxanthin may help protect pancreatic beta cells from oxidative damage. This could be especially relevant in the early stages of metabolic dysfunction, when the pancreas is working harder to compensate for insulin resistance.

The commonly used supplemental dose of astaxanthin is typically between 4 and 12 mg per day. Many people start with 4 mg daily, while clinical studies and commercial formulations may use 8 to 12 mg per day. Because astaxanthin is fat-soluble, it is best taken with a meal containing healthy fat, such as olive oil, avocado, nuts, tahini, or fish.

Astaxanthin is not a diabetes medication and should not be presented as a cure. Its effect on blood sugar may be modest and may vary depending on diet, weight, activity level, medication use, and overall metabolic health.

People taking diabetes medications, blood pressure medications, blood thinners, or other regular medications should consult a healthcare professional before using astaxanthin, especially at higher doses or for long-term use.

Medical Monitoring Is Essential

A natural approach to type 2 diabetes works best when paired with proper medical monitoring.

Important markers include HbA1c, fasting glucose, lipid profile, kidney function, liver enzymes, blood pressure, urine albumin-to-creatinine ratio, eye exams, foot exams, weight, and waist circumference.

Monitoring allows progress to be measured accurately. It also helps identify complications early and supports safer medication adjustments when blood sugar improves.

No one should stop or change diabetes medication without medical guidance. Improved lifestyle habits can lower blood sugar, which may require medication adjustments, but those changes must be made safely and professionally.

Can Type 2 Diabetes Go Into Remission?

For some people, type 2 diabetes can go into remission. Remission means that blood sugar levels return to a non-diabetic range for a sustained period without certain glucose-lowering medications.

This is more likely when diabetes is diagnosed early, when weight loss is achieved, and when lifestyle changes are maintained consistently.

However, remission is not the same as a permanent cure. The underlying tendency toward insulin resistance may remain. Returning to previous habits can cause blood sugar levels to rise again. Long-term success depends on maintaining the habits that created the improvement.

Practical Daily Routine for Blood Sugar Support

A blood-sugar-friendly day can begin with a breakfast rich in protein and fiber, such as plain Greek yogurt with chia seeds and nuts, or eggs with vegetables and tahini.

Lunch may include a protein source such as fish, chicken, tofu, or legumes, combined with a large salad and a controlled portion of a quality carbohydrate such as quinoa, lentils, buckwheat, or sweet potato.

A balanced snack may include a whole fruit with a few almonds, vegetables with tahini, a boiled egg, or plain yogurt.

Dinner is often best when it is lighter and rich in vegetables and protein. Examples include a large salad with tuna or eggs, vegetable soup, tofu with greens, or an omelet with vegetables.

A short walk after the largest meal of the day can make a meaningful difference in post-meal glucose control.

Common Mistakes to Avoid

One common mistake is focusing only on sugar while ignoring refined carbohydrates. White bread, white rice, pasta, crackers, pastries, and many “healthy” snack foods can raise blood sugar significantly.

Another mistake is relying too heavily on products labeled “sugar-free.” Some of these products still contain refined flour, unhealthy fats, or high calorie loads.

Skipping meals during the day and overeating at night can also create glucose instability and make weight management more difficult.

Perhaps the most important mistake is stopping medication without medical supervision. Lifestyle changes are powerful, but medication changes must be handled by a qualified healthcare professional.

Preventing Long-Term Complications

Uncontrolled type 2 diabetes can damage blood vessels and nerves over time. Potential complications include heart disease, stroke, kidney disease, vision loss, neuropathy, foot ulcers, poor wound healing, recurrent infections, fatty liver disease, and sexual dysfunction.

The goal is not only to lower blood sugar, but to protect the whole body.

Effective prevention includes glucose control, blood pressure management, cholesterol and triglyceride management, smoking cessation, physical activity, healthy nutrition, regular eye exams, foot care, kidney monitoring, and consistent medical follow-up.

A Simple 30-Day Action Plan

During the first week, focus on awareness. Stop drinking sugary beverages, add vegetables to at least two meals per day, take a short walk after one meal, and begin tracking blood sugar if recommended by a healthcare provider.

During the second week, improve meal quality. Replace refined carbohydrates with whole-food options in controlled portions, add protein to breakfast, and prepare healthier snacks in advance.

During the third week, increase movement. Aim for regular walking and add two short strength-training sessions.

During the fourth week, refine the plan. Identify which meals keep blood sugar stable, which foods cause spikes, and which habits are easiest to maintain. This turns the process into a personalized strategy rather than a generic diet.

Important Medical Disclaimer

The information in this article is provided for general educational purposes only. It is not medical advice, diagnosis, or a personalized treatment recommendation. It does not replace consultation with a physician, registered dietitian, pharmacist, or other qualified healthcare professional.

Type 2 diabetes is a medical condition that requires professional monitoring and individualized care. Do not start, stop, or change any medication, supplement, diet plan, or exercise program without appropriate medical guidance, especially if you have existing medical conditions, take regular medications, are pregnant, have kidney or liver disease, or have unstable blood sugar levels.

Conclusion

Type 2 diabetes is a serious condition, but it is also highly responsive to lifestyle change. A natural, science-based approach can help improve blood sugar control, support weight loss, increase energy, reduce inflammation, improve insulin sensitivity, and lower the risk of long-term complications.

The most effective strategy is not extreme. It is consistent.

Smart nutrition, regular movement, strength training, restorative sleep, stress management, hydration, medical monitoring, and carefully selected supplements can work together to support better metabolic health.

When people understand their bodies, track their progress, and receive proper professional support, type 2 diabetes becomes more manageable. With the right habits, the path toward better blood sugar control becomes not only possible, but practical, sustainable, and empowering.

Reference

American Diabetes Association Professional Practice Committee. (2024). Standards of care in diabetes—2024. Diabetes Care, 47(Supplement 1), S1–S350. https://doi.org/10.2337/dc24-SINT

American Diabetes Association Professional Practice Committee. (2024). Facilitating positive health behaviors and well-being to improve health outcomes: Standards of care in diabetes—2024. Diabetes Care, 47(Supplement 1), S77–S110. https://doi.org/10.2337/dc24-S005

American Diabetes Association Professional Practice Committee. (2024). Obesity and weight management for the prevention and treatment of type 2 diabetes: Standards of care in diabetes—2024. Diabetes Care, 47(Supplement 1), S145–S157. https://doi.org/10.2337/dc24-S008

American Diabetes Association Professional Practice Committee. (2024). Cardiovascular disease and risk management: Standards of care in diabetes—2024. Diabetes Care, 47(Supplement 1), S179–S218. https://doi.org/10.2337/dc24-S010

Davies, M. J., Aroda, V. R., Collins, B. S., Gabbay, R. A., Green, J., Maruthur, N. M., Rosas, S. E., Del Prato, S., Mathieu, C., Mingrone, G., Rossing, P., Tankova, T., Tsapas, A., & Buse, J. B. (2022). Management of hyperglycemia in type 2 diabetes, 2022: A consensus report by the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care, 45(11), 2753–2786. https://doi.org/10.2337/dci22-0034

Evert, A. B., Dennison, M., Gardner, C. D., Garvey, W. T., Lau, K. H. K., MacLeod, J., Mitri, J., Pereira, R. F., Rawlings, K., Robinson, S., Saslow, L., Uelmen, S., Urbanski, P. B., & Yancy, W. S., Jr. (2019). Nutrition therapy for adults with diabetes or prediabetes: A consensus report. Diabetes Care, 42(5), 731–754. https://doi.org/10.2337/dci19-0014

International Diabetes Federation. (2021). IDF diabetes atlas (10th ed.). International Diabetes Federation. https://diabetesatlas.org/atlas/tenth-edition/

World Health Organization. (2023). Diabetes. https://www.who.int/news-room/fact-sheets/detail/diabetes

Colberg, S. R., Sigal, R. J., Yardley, J. E., Riddell, M. C., Dunstan, D. W., Dempsey, P. C., Horton, E. S., Castorino, K., & Tate, D. F. (2016). Physical activity/exercise and diabetes: A position statement of the American Diabetes Association. Diabetes Care, 39(11), 2065–2079. https://doi.org/10.2337/dc16-1728

Umpierre, D., Ribeiro, P. A. B., Kramer, C. K., Leitão, C. B., Zucatti, A. T. N., Azevedo, M. J., Gross, J. L., Ribeiro, J. P., & Schaan, B. D. (2011). Physical activity advice only or structured exercise training and association with HbA1c levels in type 2 diabetes: A systematic review and meta-analysis. JAMA, 305(17), 1790–1799. https://doi.org/10.1001/jama.2011.576

Kanaley, J. A., Colberg, S. R., Corcoran, M. H., Malin, S. K., Rodriguez, N. R., Crespo, C. J., Kirwan, J. P., & Zierath, J. R. (2022). Exercise/physical activity in individuals with type 2 diabetes: A consensus statement from the American College of Sports Medicine. Medicine & Science in Sports & Exercise, 54(2), 353–368. https://doi.org/10.1249/MSS.0000000000002800

Lean, M. E. J., Leslie, W. S., Barnes, A. C., Brosnahan, N., Thom, G., McCombie, L., Peters, C., Zhyzhneuskaya, S., Al-Mrabeh, A., Hollingsworth, K. G., Rodrigues, A. M., Rehackova, L., Adamson, A. J., Sniehotta, F. F., Mathers, J. C., Ross, H. M., McIlvenna, Y., Welsh, P., Kean, S., … Taylor, R. (2018). Primary care-led weight management for remission of type 2 diabetes: An open-label, cluster-randomised trial. The Lancet, 391(10120), 541–551. https://doi.org/10.1016/S0140-6736(17)33102-1

Taylor, R., Al-Mrabeh, A., & Sattar, N. (2019). Understanding the mechanisms of reversal of type 2 diabetes. The Lancet Diabetes & Endocrinology, 7(9), 726–736. https://doi.org/10.1016/S2213-8587(19)30076-2

Esposito, K., Maiorino, M. I., Bellastella, G., Chiodini, P., Panagiotakos, D., & Giugliano, D. (2015). A journey into a Mediterranean diet and type 2 diabetes: A systematic review with meta-analyses. BMJ Open, 5(8), e008222. https://doi.org/10.1136/bmjopen-2015-008222

Ajala, O., English, P., & Pinkney, J. (2013). Systematic review and meta-analysis of different dietary approaches to the management of type 2 diabetes. The American Journal of Clinical Nutrition, 97(3), 505–516. https://doi.org/10.3945/ajcn.112.042457

Reynolds, A., Mann, J., Cummings, J., Winter, N., Mete, E., & Te Morenga, L. (2019). Carbohydrate quality and human health: A series of systematic reviews and meta-analyses. The Lancet, 393(10170), 434–445. https://doi.org/10.1016/S0140-6736(18)31809-9

Schwingshackl, L., Chaimani, A., Hoffmann, G., Schwedhelm, C., & Boeing, H. (2018). A network meta-analysis on the comparative efficacy of different dietary approaches on glycaemic control in patients with type 2 diabetes mellitus. European Journal of Epidemiology, 33(2), 157–170. https://doi.org/10.1007/s10654-017-0352-x

Cappuccio, F. P., D’Elia, L., Strazzullo, P., & Miller, M. A. (2010). Quantity and quality of sleep and incidence of type 2 diabetes: A systematic review and meta-analysis. Diabetes Care, 33(2), 414–420. https://doi.org/10.2337/dc09-1124

Reutrakul, S., & Van Cauter, E. (2018). Sleep influences on obesity, insulin resistance, and risk of type 2 diabetes. Metabolism, 84, 56–66. https://doi.org/10.1016/j.metabol.2018.02.010

Chatterjee, S., Khunti, K., & Davies, M. J. (2017). Type 2 diabetes. The Lancet, 389(10085), 2239–2251. https://doi.org/10.1016/S0140-6736(17)30058-2

Forouhi, N. G., & Wareham, N. J. (2019). Epidemiology of diabetes. Medicine, 47(1), 22–27. https://doi.org/10.1016/j.mpmed.2018.10.004

Gow, M. L., Ho, M., Burrows, T. L., Baur, L. A., Stewart, L., Hutchesson, M. J., Cowell, C. T., Collins, C. E., & Garnett, S. P. (2014). Impact of dietary macronutrient distribution on BMI and cardiometabolic outcomes in overweight and obese children and adolescents: A systematic review. Nutrition Reviews, 72(7), 453–470. https://doi.org/10.1111/nure.12111

Allen, R. W., Schwartzman, E., Baker, W. L., Coleman, C. I., & Phung, O. J. (2013). Cinnamon use in type 2 diabetes: An updated systematic review and meta-analysis. Annals of Family Medicine, 11(5), 452–459. https://doi.org/10.1370/afm.1517

Veronese, N., Watutantrige-Fernando, S., Luchini, C., Solmi, M., Sartore, G., Sergi, G., Manzato, E., Barbagallo, M., Maggi, S., Stubbs, B., & Zambon, S. (2016). Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: A systematic review and meta-analysis of double-blind randomized controlled trials. European Journal of Clinical Nutrition, 70(12), 1354–1359. https://doi.org/10.1038/ejcn.2016.154

Pittas, A. G., Dawson-Hughes, B., Sheehan, P., Ware, J. H., Knowler, W. C., Aroda, V. R., Brodsky, I., Ceglia, L., Chadha, C., Chatterjee, R., Desouza, C., Dolor, R., Foreyt, J., Fuss, P., Ghazi, A., Hsia, D. S., Johnson, K. C., Kashyap, S. R., Kim, S., … D2d Research Group. (2019). Vitamin D supplementation and prevention of type 2 diabetes. The New England Journal of Medicine, 381(6), 520–530. https://doi.org/10.1056/NEJMoa1900906

Akbari, M., Ostadmohammadi, V., Tabrizi, R., Mobini, M., Lankarani, K. B., Moosazadeh, M., Heydari, S. T., Chamani, M., Kolahdooz, F., & Asemi, Z. (2018). The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials. Metabolism, 87, 56–69. https://doi.org/10.1016/j.metabol.2018.07.002

Yin, J., Xing, H., & Ye, J. (2008). Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism, 57(5), 712–717. https://doi.org/10.1016/j.metabol.2008.01.013

Lan, J., Zhao, Y., Dong, F., Yan, Z., Zheng, W., Fan, J., & Sun, G. (2015). Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. Journal of Ethnopharmacology, 161, 69–81. https://doi.org/10.1016/j.jep.2014.09.049

Ambati, R. R., Phang, S. M., Ravi, S., & Aswathanarayana, R. G. (2014). Astaxanthin: Sources, extraction, stability, biological activities and its commercial applications—A review. Marine Drugs, 12(1), 128–152. https://doi.org/10.3390/md12010128

Fassett, R. G., & Coombes, J. S. (2011). Astaxanthin: A potential therapeutic agent in cardiovascular disease. Marine Drugs, 9(3), 447–465. https://doi.org/10.3390/md9030447

Yoshida, H., Yanai, H., Ito, K., Tomono, Y., Koikeda, T., Tsukahara, H., & Tada, N. (2010). Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia. Atherosclerosis, 209(2), 520–523. https://doi.org/10.1016/j.atherosclerosis.2009.10.012

Choi, H. D., Youn, Y. K., Shin, W. G., & Lee, J. Y. (2011). Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods for Human Nutrition, 66(4), 363–369. https://doi.org/10.1007/s11130-011-0258-9

Ursoniu, S., Sahebkar, A., Serban, M. C., Banach, M., & Lipid and Blood Pressure Meta-analysis Collaboration Group. (2015). Lipid profile and glucose changes after supplementation with astaxanthin: A systematic review and meta-analysis of randomized controlled trials. Archives of Medical Science, 11(2), 253–266. https://doi.org/10.5114/aoms.2015.50960

Ni, Y., Nagashimada, M., Zhuge, F., Zhan, L., Nagata, N., Tsutsui, A., Nakanuma, Y., Kaneko, S., & Ota, T. (2015). Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E. Scientific Reports, 5, 17192. https://doi.org/10.1038/srep17192