Research review - The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People
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The skin is a primary protective tissue in humans. Since the function of the biological barrier is degraded by several types of stress (oxidative stress) for example exposure to ultraviolet (UV) rays, the protection and treatment of skin conditions by taking nutritional supplements is very important.
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We therefore evaluated the effects of dietary supplements with an antioxidant derived from algae food, astaxanthin, on skin deterioration caused by UV exposure.
Twenty-three healthy Japanese participants were recruited into a 10-week, double-blind, placebo-controlled study. They were assigned to the astaxanthin group plus a capsule containing 4 mg of astaxanthin or the placebo group.
To assess the role of astaxanthin in protecting the skin against UV-induced deterioration, we determined the minimal erythema dose (MED) and analyzed UV-induced changes in moisture and transepidermal water loss (TEWL) at baseline and after 9 weeks of addition.
Subjective skin conditions were assessed by a visual analog scale. The astaxanthin group showed an increased MED compared to placebo. In addition, the astaxanthin group had a reduced loss of skin moisture in the irradiated area compared to placebo. Subjective skin conditions for "roughness improvement" and "texture" in non-irradiated areas were significantly improved by astaxanthin.
In conclusion, Astaxanthin appears to be a significant protector against skin damage caused by solar radiation (UV) and helps maintain healthy skin in healthy people.
Keywords: astaxanthin, antioxidant, skin, ultraviolet, UV, MED, moisture
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3. Maurya P.K., Kumar P., Nagotu S., Chand S., Chandra P. Multi-target detection of oxidative stress biomarkers in quercetin and myricetin treated human red blood cells. RSC Adv. 2016;6:53195–53202. doi: 10.1039/C6RA05121A. [CrossRef] [Google Scholar]
4. Fernández-García E. Skin protection against UV light by dietary antioxidants. Food Funct. 2014;5:1994. doi: 10.1039/C4FO00280F. [PubMed] [CrossRef] [Google Scholar] 5. Stahl W., Heinrich U., Aust O., Tronnier H., Sies H. Lycopene-rich products and dietary photoprotection. Photochem. Photobiol. Sci. 2006;5:238–242. doi: 10.1039/B505312A. [PubMed] [CrossRef] [Google Scholar]
6. McArdle F., Rhodes L.E., Parslew R., Jack C.I.A., Friedmann P.S., Jackson M.J. UVR-induced oxidative stress in human skin in vivo: Effects of oral vitamin C supplementation. Free Radic. Biol. Med. 2002;33:1355–1362. doi: 10.1016/S0891-5849(02)01042-0. [PubMed] [CrossRef] [Google Scholar]
7. Ambati R.R., Moi P.S., Ravi S., Aswathanarayana R.G. Astaxanthin: Sources, extraction, stability, biological activities and its commercial applications—A review. Mar. Drugs. 2014;12:128–152. doi: 10.3390/md12010128. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
8. Hussein G., Sankawa U., Goto H., Matsumoto K., Watanabe H. Astaxanthin, a carotenoid with potential in human health and nutrition. J. Nat. Prod. 2006;69:443–449. doi: 10.1021/np050354+. [PubMed] [CrossRef] [Google Scholar]
9. Mori J., Yokoyama H., Sawada T., Miyashita Y., Nagata K. Anti-oxidative properties of astaxanthin and related compounds. Mol. Cryst. Liq. Cryst. 2013;580:52–57. doi: 10.1080/15421406.2013.804380. [CrossRef] [Google Scholar]
10. Nakagawa K., Kiko T., Miyazawa T., Carpentero Burdeos G., Kimura F., Satoh A., Miyazawa T. Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes. Br. J. Nutr. 2011;105:1563–1571. doi: 10.1017/S0007114510005398. [PubMed] [CrossRef] [Google Scholar]
11. Tso M., Lam T. Method of Retarding and Ameliorating Central Nervous System and Eye Damage. 5527533. U.S. Patent. 1996 Jun 18;
12. Manabe Y., Komatsu T., Seki S., Sugawara T. Dietary astaxanthin can accumulate in the brain of rats. Biosci. Biotechnol. Biochem. 2018:1–4. doi: 10.1080/09168451.2018.1459467. [PubMed] [CrossRef] [Google Scholar]
13. Komatsu T., Sasaki S., Manabe Y., Hirata T., Sugawara T. Preventive effect of dietary astaxanthin on UVA-induced skin photoaging in hairless mice. PLoS ONE. 2017;12:e171178. doi: 10.1371/journal.pone.0171178. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
14. Yoshida H., Yanai H., Ito K., Tomono Y., Koikeda T., Tsukahara H., Tada N. Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia. Atherosclerosis. 2010;209:520–523. doi: 10.1016/j.atherosclerosis.2009.10.012. [PubMed] [CrossRef] [Google Scholar]
15. Ni Y., Nagashimada M., Zhuge F., Zhan L., Nagata N., Tsutsui A., Nakanuma Y., Kaneko S., Ota T. Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E. Sci. Rep. 2015;5:17192. doi: 10.1038/srep17192. [PMC free article] [PubMed] [CrossRef] [Google Scholar]